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CGP 78608 hydrochloride
CAS No. 1135278-54-4
CGP 78608 hydrochloride ( —— )
产品货号. M32842 CAS No. 1135278-54-4
CGP 78608 hydrochlorid 是 NMDA 受体甘氨酸结合位点的一种高效选择性拮抗剂，IC50 为 6 nM。CGP 78608 作为 GluN1/GluN3A 介导的甘氨酸电流的增强剂，EC50 值为 26.3 nM。具有抗惊厥活性。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥1124 | 有现货 |
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| 5MG | ￥1591 | 有现货 |
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| 10MG | ￥1962 | 有现货 |
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| 25MG | ￥4184 | 有现货 |
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| 50MG | ￥6045 | 有现货 |
|
| 100MG | ￥8262 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称CGP 78608 hydrochloride
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述CGP 78608 hydrochlorid 是 NMDA 受体甘氨酸结合位点的一种高效选择性拮抗剂，IC50 为 6 nM。CGP 78608 作为 GluN1/GluN3A 介导的甘氨酸电流的增强剂，EC50 值为 26.3 nM。具有抗惊厥活性。
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产品描述CGP 78608 hydrochloride is a highly potent and selective antagonist at the glycine-binding site of the NMDA receptor, with an IC50 of 6 nM. CGP 78608 acts as a potentiator of GluN1/GluN3A-mediated glycine currents, with an estimated EC50 in the low nM range (26.3 nM). Anticonvulsant activity.
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体外实验CGP-78608 hydrochloride decreases glycine sensitivity of GluN1/GluN3A receptors through an inter-subunit allosteric effect between GluN1 and GluN3A agonist-binding domain (ABD) sites.CGP 78608 hydrochloride reduces or abolishes ammonia-dependent cGMP synthesis which is a causative factor of ammonia neurotoxicity.
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体内实验CGP-78608 hydrochloride displays potent anticonvulsant effects after i.p. administration in the electroshock-induced convulsions assay in mice.
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同义词——
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通路Membrane Transporter/Ion Channel
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靶点iGluR
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受体iGluR | NMDAR
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研究领域——
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适应症——
化学信息
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CAS Number1135278-54-4
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分子量414.58
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分子式C11H14BrClN3O5P
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纯度>98% (HPLC)
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溶解度——
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SMILESC(N[C@@H](P(=O)(O)O)C)C1=C2C(NC(=O)C(=O)N2)=CC(Br)=C1.Cl
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Catarzi D, et al. Competitive Gly/NMDA receptor antagonists. Curr Top Med Chem. 2006;6(8):809-21.?
